New Insight On How Lithium Works BioMedNet News (warning: requires registration), in the News Archives July 31, 2003, has a summary of exciting new British research throwing fresh light on how mood stabilizers used in treatment of bipolar affective disorder affects cellular pathways. (Article is entitled: “Slime Mould Gets Moody” by Laura Spinney).
Although the organism in the spotlight is Dictyostelium discoideum , the slime mold, the pathways being studied are present in both mammals and slime mold. Adrian Harwood and his lab at the Medical Research Council Laboratory for Molecular Cell Biology of the University College London have been focusing on the inositide signaling pathway and the Wnt-signaling pathway in slime mold.
The most important implication of this work is stated here: "…Their latest findings add more detail to the picture, indicating that lithium and valproic acid exert their effects at different stages of the inositide-signaling pathway.
"Dictyo...